Preparation and Some Reactions of 2-(1,3-Butadienyl)magnesium Chloride
โ Scribed by Aufdermarsh, C. A.
- Book ID
- 121404558
- Publisher
- American Chemical Society
- Year
- 1964
- Tongue
- English
- Weight
- 396 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0022-3263
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๐ SIMILAR VOLUMES
Although reactions between (-)ephedrine E2-(S)-methylamino-l-(R)-phenylpropan-l-017 and RPOC12 (R = Cl, alkyl, aryl, alkoxy, aryloxy) can in principle afford pairs of 1,3,2-oxazaphospholanes eyimeric at phosphorus, most reports describe only one product from highly stereoselective reactions.
Magnesium activated by equilibratiog with its anthracene adduct in THF metalates smoothly 2-alkenyl chlorides at -65 C without significant coupling. The resulting solutions of Grignard reagents are subjected to thermal (80-130ยฐC) cyclization followed by trapping with electrophiles.