Practical preparation and metallo-ene reactions of (2-alkenylallyl)-magnesium chlorides: Comparative study of magnesium activation

✍ Scribed by Wolfgang Oppolzer; Philippe Schneider

• Publisher: Elsevier Science
• Year: 1984
• Tongue: French
• Weight: 212 KB
• Volume: 25
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)81370-8

✦ Synopsis

Magnesium activated by equilibratiog with its anthracene adduct in THF metalates smoothly 2-alkenyl chlorides at -65 C without significant coupling. The resulting solutions of Grignard reagents are subjected to thermal (80-130°C) cyclization followed by trapping with electrophiles.