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Preparation and properties of 2-Dialkylamino-5-haloacetyl-thiazoles and 4-(2-Dialkylamino-5-thiazolyl)-thiazoles

✍ Scribed by Cornelia Mokry; Prof. Dr. Horst Hartmann


Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
618 KB
Volume
340
Category
Article
ISSN
1615-4150

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📜 SIMILAR VOLUMES


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✍ C. MOKRY; H. HARTMANN 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 36 KB 👁 1 views

Preparation and Properties of 2-Dialkylamino-5-haloacetyl-thiazoles and 4-(2-Dialkylamino-5-thiazolyl)-thiazoles. -Haloacetyl thiazoles, e.g. (VII), can be used for the preparation of deeply colored dyes such as (XIII) and (XV).

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The readily available 2-substituted 5-acetyl-4-thiazolyl with 1-alkynes/6-endo-dig annulation reactions in the presence of ammonia leads to functionalised pyrido[3,4-triflates 2 are useful building blocks for the preparation of functionalised thiazoles by means of palladium-catalysed c]thiazoles in

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## Abstract By the reaction of weak bases with __N__(2)‐disubstituted 2‐amino‐4‐thiazoliniminium chlorides 3, easily available by the reaction of thioureas 1 with α‐chloroacetonitrile 2, __N__(2),__N__(2′)‐persubstituted 2,4‐diamino‐5‐(2‐amino‐4‐thiazolyl)thiazoles 8 are formed. These new bis‐thiaz