✍ Scribed by Ronald Flaig; Horst Hartmann
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By the reaction of weak bases with N(2)‐disubstituted 2‐amino‐4‐thiazoliniminium chlorides 3, easily available by the reaction of thioureas 1 with α‐chloroacetonitrile 2, N(2),N(2′)‐persubstituted 2,4‐diamino‐5‐(2‐amino‐4‐thiazolyl)thiazoles 8 are formed. These new bis‐thiazoles react, as exemplified with the dimorpholino derivative 8a, with different electrophilic reagent, such as phenyl isothiocyanate 9, 4‐nitro‐phenyldiazonium salt 11, or 4‐dialkylaminobenzaldehydes 13 at their 5__H__‐substituted thiazole moieties to give the corresponding thioanilides 10, azo compounds 12, and methine dyes 14, respectively. With sodium nitrite and the Vilsmeier reagent the thiazole 8a is transformed, via unstable intermediates, into the tricyclic 2,7‐dimorpholinothiazolo[4,5‐c]thiazolo[4,5‐e]pyridazine 16 and 2,7‐dimorpholinothiazolo[4,5‐b]thiazolo[4,5‐d]pyridine 19, respectively.
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