ChemInform Abstract: Preparation and Properties of 2-Dialkylamino-5-haloacetyl-thiazoles and 4-(2-Dialkylamino-5-thiazolyl)-thiazoles.
β Scribed by C. MOKRY; H. HARTMANN
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 36 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0931-7597
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β¦ Synopsis
Preparation and Properties of 2-Dialkylamino-5-haloacetyl-thiazoles and 4-(2-Dialkylamino-5-thiazolyl)-thiazoles.
-Haloacetyl thiazoles, e.g. (VII), can be used for the preparation of deeply colored dyes such as (XIII) and (XV).
π SIMILAR VOLUMES
The readily available 2-substituted 5-acetyl-4-thiazolyl with 1-alkynes/6-endo-dig annulation reactions in the presence of ammonia leads to functionalised pyrido[3,4-triflates 2 are useful building blocks for the preparation of functionalised thiazoles by means of palladium-catalysed c]thiazoles in
## Abstract The synthesis of two diastereomers of the title compound involves the coupling of 5βlithiated 2β(1,1βdimethoxyethyl)thiazole (VI) with a Weinreb amide (V) derived from gluconolacetone, followed by asymmetric reduction of the ketone functionality.
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