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Preparation and biological activities of optically active dehydroxymethylepoxyquinomicin, a novel NF-κB inhibitor

✍ Scribed by Yoshikazu Suzuki; Chie Sugiyama; Osamu Ohno; Kazuo Umezawa


Book ID
108282521
Publisher
Elsevier Science
Year
2004
Tongue
French
Weight
185 KB
Volume
60
Category
Article
ISSN
0040-4020

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A new NF-kappaB inhibitor, dehydroxymethylepoxyquinomicin (DHMEQ), inhibited proliferation and induced apoptosis in human Burkitt lymphoma, HS-Sultan and Daudi cell lines. The activation of caspase-3 and the cleavage of caspase substrate PARP were observed after treatment with DHMEQ. The induction o