✦ LIBER ✦

Preparation and Biological Activities of Optically Active Dehydroxymethylepoxyquinomicin, a Novel NF-ϰB Inhibitor.

✍ Scribed by Yoshikazu Suzuki; Chie Sugiyama; Osamu Ohno; Kazuo Umezawa

Publisher: John Wiley and Sons
Year: 2004
Weight: 10 KB
Volume: 35
Category: Article
ISSN: 0931-7597
DOI: 10.1002/chin.200449198

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Targeting NF-κB and induction of apoptos

Targeting NF-κB and induction of apoptosis by novel NF-κB inhibitor dehydroxymethylepoxyquinomicin (DHMEQ) in Burkitt lymphoma cells

✍ Noriko Kimura; Yoshitaka Miyakawa; Kanoko Kohmura; Kazuo Umezawa; Yasuo Ikeda; M 📂 Article 📅 2007 🏛 Elsevier Science 🌐 English ⚖ 401 KB

A new NF-kappaB inhibitor, dehydroxymethylepoxyquinomicin (DHMEQ), inhibited proliferation and induced apoptosis in human Burkitt lymphoma, HS-Sultan and Daudi cell lines. The activation of caspase-3 and the cleavage of caspase substrate PARP were observed after treatment with DHMEQ. The induction o

The Design and Synthesis of Novel Orally

The Design and Synthesis of Novel Orally Active Inhibitors of AP-1 and NF-ϰB Mediated Transcriptional Activation. SAR of in vitro and in vivo Studies.

✍ Moorthy S. S. Palanki; et al. et al. 📂 Article 📅 2004 🏛 John Wiley and Sons ⚖ 94 KB 👁 1 views

Effects of a novel NF-κB inhibitor, dehy

Effects of a novel NF-κB inhibitor, dehydroxymethylepoxyquinomicin (DHMEQ), on growth, apoptosis, gene expression, and chemosensitivity in head and neck squamous cell carcinoma cell lines

✍ Hong-ying Ruan; Muneyuki Masuda; Aya Ito; Kazuo Umezawa; Torahiko Nakashima; Ryu 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 194 KB

## Background: Recent studies provide evidence that the constitutive activation of nuclear factor-kappa b, nf-kappab plays a critical role in enhancing the growth of several types of malignancies, including head and neck squamous cell carcinoma (hnscc). ## Methods: In this study, we examined the

ChemInform Abstract: Development of a No

ChemInform Abstract: Development of a Novel Furocoumarin Derivative Inhibiting NF-ϰB Dependent Biological Functions: Design, Synthesis and Biological Effects.

✍ Roberto Gambari; et al. et al. 📂 Article 📅 2012 🏛 John Wiley and Sons ⚖ 31 KB

Synthesis and Biological Activity of a N

Synthesis and Biological Activity of a Novel Inhibitor of Dihydroceramide Desaturase

✍ Jose M. Munoz-Olaya; Xavier Matabosch; Carmen Bedia; Meritxell Egido-Gabás; Jose 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 401 KB 👁 1 views

A novel NF-κB inhibitor DHMEQ selectivel

A novel NF-κB inhibitor DHMEQ selectively targets constitutive NF-κB activity and induces apoptosis of multiple myeloma cells in vitro and in vivo

✍ Mariko Watanabe; Md. Zahidunnabi Dewan; Takamitu Okamura; Masataka Sasaki; Kinji 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 French ⚖ 453 KB

Multiple myeloma (MM) is a fatal lymphoid malignancy that is incurable with conventional modalities of chemotherapy. Strong and constitutive activation of nuclear factor kappa B (NF-kappaB) is a common characteristic of MM cells. In our study we successfully target NF-kappaB with a novel NF-kappaB i