𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Preparation and biodistribution of novel 99mTc(CO)3-CNR complexes for myocardial imaging

✍ Scribed by Guiyang Hao; Jianying Zang; Boli Liu

Publisher
John Wiley and Sons
Year
2007
Tongue
French
Weight
126 KB
Volume
50
Category
Article
ISSN
0022-2135

No coin nor oath required. For personal study only.

✦ Synopsis

We evaluated lipophilicity and biodistribution of a series of 99m Tc(CO) 3 -ether isonitrile complexes to determine whether different lipophilicity and structure of isonitrile ligands would improve the imaging properties of the radiopharmaceutical for the heart. Novel 99m Tc(CO) 3 -MIBI analogs were prepared and analyzed by radio-HPLC, and their lipophilicity was determined. These new complexes could be bi-or tri-substituted in specified pH conditions like 99m Tc(CO) 3 -MIBI. These new complexes exhibited low liver, lungs and blood uptake compared with [ 99m Tc(CO) 3 (MIBI) 3 ] + though their heart uptake was not so high. Among these complexes, [ 99m Tc(CO) 3 (EPI) 2 (OH 2 )] + showed higher target to non-target ratios at 5 and 30 min post-injection than that of [ 99m Tc(CO) 3 (MIBI) 3 ] + . Copyright

📜 SIMILAR VOLUMES

Synthesis and biodistribution in mice of
Synthesis and biodistribution in mice of a new 99mTc nitrido complex for brain imaging
✍ Junbo Zhang; Xuebin Wang; Jing Liu 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 French ⚖ 117 KB

## Abstract The bis(__N__‐cyclopentyl dithiocarbamato) nitrido technetium‐99m complex ^99m^TcN(CPEDTC)~2~ was synthesized by the reduction of ^99m^TcO into [^99m^Tc≡N]^2+^ with stannous chloride in the presence of succinic dihydrazide and propylenediamine tetraacetic acid, followed by the addition

Synthesis and biological evaluation of 9
Synthesis and biological evaluation of 99mTc(CO)3(IDA-CPT) for tumor imaging
✍ Jianjun Wang; Tingting Niu; Jing Yang; Cunmin Tan; Xiaobei Zheng; Wangsuo Wu; Fe 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 French ⚖ 89 KB

## Abstract This work reports the synthesis, radiolabeling, and preliminary biodistribution results in tumor‐bearing mice of ^99m^Tc(CO)~3~(IDA‐CPT). The novel camptothecin (CPT) derivate was successfully synthesized by conjugation of iminodiacetic acid (IDA) to camptothecin via a short carbonyl‐me

Preparation, quality control and stabili
Preparation, quality control and stability of 99mTc-sparafloxacin complex, a novel agent for detecting sites of infection
✍ M. A. Motaleb 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 French ⚖ 119 KB

## Abstract Labeling of sparafloxacin with technetium‐99m using stannous chloride as a reducing agent was investigated. Dependence of the yield of ^99m^Tc‐sparafloxacin complex on the concentration of sparafloxacin, reducing agent, pH and reaction time was studied. Under optimum conditions, the lab

Recombinant coagulation factor VIIa labe
Recombinant coagulation factor VIIa labelled with the fac-99 mTc(CO)3-core: synthesis and in vitro evaluation of a putative new radiopharmaceutical for imaging in acute bleeding lesion
✍ Jacob Madsen; Jesper B. Kristensen; Ole H. Olsen; Carsten L. Christoffersen; Lar 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 French ⚖ 215 KB

## Abstract Coagulation in blood is initiated when coagulation factor VII (FVII) binds to exposed TF and is activated to FVIIa, and the TF/FVIIa complex may therefore provide a marker of vascular injury potentially applicable in diagnostic imaging of acute gastrointestinal (GI) bleeding. Methods: R