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Synthesis and biodistribution in mice of a new 99mTc nitrido complex for brain imaging

✍ Scribed by Junbo Zhang; Xuebin Wang; Jing Liu

Publisher
John Wiley and Sons
Year
2004
Tongue
French
Weight
117 KB
Volume
47
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

The bis(N‐cyclopentyl dithiocarbamato) nitrido technetium‐99m complex ^99m^TcN(CPEDTC)~2~ was synthesized by the reduction of ^99m^TcO into [^99m^Tc≡N]^2+^ with stannous chloride in the presence of succinic dihydrazide and propylenediamine tetraacetic acid, followed by the addition of sodium N‐cyclopentyl dithiocarbamate monohydrate. The radiochemical purity (RCP) of the product was over 90% as measured by thin layer chromatography(TLC) and high performance liquid chromatography(HPLC). In vitro studies showed that the complex possessed good stability under physiological conditions. Its partition coefficient studies indicated it was a good lipophilic complex. The electrophoresis results showed the complex was neutral. The biodistribution results in mice indicated that ^99m^TcN(CPEDTC)~2~ was significantly retained into the brain. The brain uptake(ID%/g) was 3.58, 5.26, 3.73 and 2.72 and the brain/blood ratios were 0.79, 1.69, 1.59 and 1.58 at 5, 30, 60 and 90 min post‐injection, respectively. These results suggested potential usefulness of the complex as a new brain perfusion imaging agent. Copyright © 2004 John Wiley & Sons, Ltd.

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