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Preorganization of the Bioactive Conformation of Sialyl LewisX Analogues Correlates with Their Affinity to E-Selectin

✍ Scribed by Gebhard Thoma; John L. Magnani; John T. Patton; Beat Ernst; Wolfgang Jahnke

Publisher: John Wiley and Sons
Year: 2001
Tongue: English
Weight: 120 KB
Volume: 40
Category: Article
ISSN: 0044-8249
DOI: 10.1002/1521-3773(20010518)40:10<1941::aid-anie1941>3.0.co;2-t

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The expression of E-selectin receptors on the surface of endothelial cells stimulated by cytokines i s one of the first steps in inflammatory processes.[" E-selectin i s a membrane-resident ylycoprotein belonging to the selectin family (E-selectin. L-selectin, P-selectin) which specifically binds th