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Determination of the Bioactive Conformation of the Carbohydrate Ligand in the E-Selectin/Sialyl LewisX Complex

✍ Scribed by Prof. Dr. Thomas Peters; Dipl.-Chem. Karoline Scheffler; Dr. Beat Ernst; Dr. Andreas Katopodis; Dr. John L. Magnani; Wey Tong Wang; Rüdiger Weisemann

Publisher: John Wiley and Sons
Year: 1995
Tongue: English
Weight: 459 KB
Volume: 34
Category: Article
ISSN: 0044-8249
DOI: 10.1002/anie.199518411

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✦ Synopsis

The expression of E-selectin receptors on the surface of endothelial cells stimulated by cytokines i s one of the first steps in inflammatory processes.[" E-selectin i s a membrane-resident ylycoprotein belonging to the selectin family (E-selectin. L-selectin, P-selectin) which specifically binds the sialyl Lewis" antigen present on neutrophilic granulocytes. To understand the recopnition :ind binding processes at the inolecular level. the

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