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Prenatal diagnosis and prognosis in α1-antitrypsin deficiencyPi ZZ

✍ Scribed by S. L. Roth; K. Havemann; M. Gramse; U. Hillig; R. Rauskolb; G. A. Martini

Book ID
105533903
Publisher
Springer
Year
1980
Tongue
English
Weight
171 KB
Volume
3
Category
Article
ISSN
0141-8955

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A method for detection of the M and Z alleles of the alpha l-antitrypsin deficiency (AAT) gene has been developed using denaturing gradient gel electrophoresis (DGGE) of DNA samples amplified in vitro by the polymerase chain reaction. Amplification of the 90 nucleotides surrounding the Z mutation si