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Coexpression and Accumulation of Ubiquitin +1 and ZZ Proteins in Livers of Children with α1-Antitrypsin Deficiency

✍ Scribed by Sandy S. Wu; Jean-Pierre de Chadarevian; Laron McPhaul; Nora E. Riley; Fred W. van Leeuwen; Samuel W. French


Book ID
106249397
Publisher
Springer
Year
2002
Tongue
English
Weight
306 KB
Volume
5
Category
Article
ISSN
1093-5266

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Chronic liver disease affects up to 20% of children with alpha 1-antitrypsin deficiency owing to the PiZZ genotype. Previous observations of a familial occurrence and abnormal immune responses to liver antigens in these patients suggests that immunoregulatory genes may be involved in the pathogenesi