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Prenatal cerebrospinal fluid modulate differentiation and proliferation of rat pheochoromocytoma PC12 cells

โœ Scribed by Nabiuni, Mohammad ;Rasouli, Javad ;Parivar, Kazem ;Kochesfhani, Homa Mohseni

Book ID
120694567
Publisher
BioMed Central
Year
2010
Tongue
English
Weight
106 KB
Volume
7
Category
Article
ISSN
1743-8454

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## Abstract PC12 rat phaeochromocytoma cells show neuronal differentiation upon NGF treatment. NGF induces prolonged activation of the Ras/Raf/MEK/ERK pathway in which the 42/44 kDa mitogenโ€activated protein kinases (MAPKs), ERK 1 and 2 are thought to be the key mediators of the differentiation sig