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Mechanisms of Manganese-Induced Rat Pheochromocytoma (PC12) Cell Death and Cell Differentiation

โœ Scribed by Jerome A. Roth; Craig Horbinski; Dennis Higgins; Pamela Lein; Michael D. Garrick

Book ID
117329959
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
166 KB
Volume
23
Category
Article
ISSN
0161-813X

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## Abstract Alterations in iron levels are likely to influence the biological actions of Mn in PC12 cells, because both metals are transported via the divalent metal transporter 1 (DMT1; also Nramp2 or DCT1). Studies were performed to determine the effect of the iron chelator desferrioxamine (DfO)