Mn 2؉ treatment has been shown to promote neurite outgrowth in rat pheochromocytoma (PC12) cells in a time-and dose-dependent manner. This process is mediated through the interactions of extracellular matrix (ECM) proteins and integrin receptors. Studies were performed to determine whether the phosp
Manganese-induced rat pheochromocytoma (PC12) cell death is independent of caspase activation
✍ Scribed by Jerome A. Roth; Li Feng; Jennifer Walowitz; Richard W. Browne
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 155 KB
- Volume
- 61
- Category
- Article
- ISSN
- 0360-4012
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract Alterations in iron levels are likely to influence the biological actions of Mn in PC12 cells, because both metals are transported via the divalent metal transporter 1 (DMT1; also Nramp2 or DCT1). Studies were performed to determine the effect of the iron chelator desferrioxamine (DfO)
## Abstract We found that ebselen [2‐phenyl‐1,2‐benzisoselenazol‐3(2H)‐one] caused phosphorylation of mitogen‐activated protein kinase (MAPK), followed by expression of neurofilament‐M, a neuron‐specific protein, in cultured PC12 rat pheochromocytoma cells. The ebselen‐induced MAPK activation was s
We examined the behavior of the transcription factor Max during retrograde neuronal degeneration of retinal ganglion cells. Using immunohistochemistry, we found a progressive redistribution of full-length Max from the nucleus to the cytoplasm and dendrites of the ganglion cells following axon damage
## Abstract Our previous study showed that cobalt chloride (CoCl~2~) could induce PC12 cell apoptosis and that the CoCl~2~‐treated PC12 cells may serve as a simple in vitro model for the study of the mechanism of hypoxia‐linked neuronal disorders. The aim of this study is to elucidate the mechanism