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Effects of Cerium Oxide Nanoparticles on PC12 Neuronal-Like Cells: Proliferation, Differentiation, and Dopamine Secretion

โœ Scribed by Ciofani, Gianni; Genchi, Giada G.; Liakos, Ioannis; Cappello, Valentina; Gemmi, Mauro; Athanassiou, Athanassia; Mazzolai, Barbara; Mattoli, Virgilio


Book ID
120314508
Publisher
Springer US
Year
2013
Tongue
English
Weight
954 KB
Volume
30
Category
Article
ISSN
0724-8741

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## Abstract PC12 rat phaeochromocytoma cells show neuronal differentiation upon NGF treatment. NGF induces prolonged activation of the Ras/Raf/MEK/ERK pathway in which the 42/44 kDa mitogenโ€activated protein kinases (MAPKs), ERK 1 and 2 are thought to be the key mediators of the differentiation sig