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Preliminary trials with 26,26,26,27,27,27-hexafluoro-1,25(OH)2D3 in hypoparathyroidism

โœ Scribed by Morii, Hirotoshi; Sekiya, Kiichiro; Miki, Takami; Nishizwa, Yoshiki; Nakatsuka, Kiyoshi; Imanishi, Yasuo; Sasao, Kyoko

Book ID
123297655
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
61 KB
Volume
10
Category
Article
ISSN
0169-6009

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Preparations of the titled fluorinated vltamln D 2 analogs (2, 2 and 2) were efflclently achieved through reactions of the C22 -aldehyde C,$) with phenylsulfone derivatives (z, ,8 and 2). As in the case of vitamin D 3\*l it was demonstrated that vitamin D2 must be metabolically hydroxylated at C-25