Synthesis of 26,26,26-trifluoro-25-hydro
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Yoshiro Kobayashi; Takeo Taguchi; Norio Kanuma; Nobuo Ikekawa; Jun-ichi Oshida
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Article
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1981
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Elsevier Science
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French
โ 219 KB
Two new fluorinated 25-hydroxyvitamin D3 analogs, 26,26,26-trifluoro-25-hydroxy (2) and 27-nor-26,26,26-trifluoro-25-hydroxyvitamin D3 (i), were prepared from 24-phenylsulfonyl 25,26,27-triorcholest-5-en-3B-yl tetrahydropyranyl ether (A). It is well known that vitamin D3 must be sequentially hydroxy