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Inhibitors of sterol synthesis. Synthesis and spectral properties of 3β-hydroxy-25,26,26,26,27,27,27-heptafluoro-5α-cholestan-15-one

✍ Scribed by Abdul U Siddiqui; Shankar Swaminathan; Xiangdong Su; William K Wilson; George J Schroepfer Jr.

Book ID
108313379
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
493 KB
Volume
86
Category
Article
ISSN
0009-3084

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✍ Shankar Swaminathan; Frederick D. Pinkerton; William K. Wilson; George J. Schroe 📂 Article 📅 1992 🏛 Elsevier Science 🌐 English ⚖ 570 KB

(25R)-5 alpha-Cholest-8(14)-ene-3 beta,15 beta,26-triol (III) was prepared by reduction of (25R)-3 beta,26-diacetoxy-5 alpha-cholest-8(14)-en-15-one with sodium borohydride followed by treatment of the crude product with lithium aluminium hydride. The trihydroxysterol III, a potential metabolite of