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Preliminary characterization of the adducts formed between the antitumor compound cis-Pt(NH3)2Cl2 and DNA

✍ Scribed by Neil P. Johnson


Book ID
118316247
Publisher
Elsevier Science
Year
1982
Tongue
English
Weight
380 KB
Volume
104
Category
Article
ISSN
0006-291X

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Diadenosine 5',5"'-P,,P,-tetraphosphate (Ap,A), a n intracellular regulatory nucleotide, has been found to react with the antitumor drug cw-diamminedichloroplatinum(I1J and its aqua derivative to form a single complex. This complex has been purified by highperformance liquid chromatography and chara