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Interaction of the antitumor agents cis,cis,trans-Pt(IV)(NH3)2Cl2(OH)2 and cis,cis,trans-Pt(IV)[(CH3)2CHNH2]2Cl2(OH)2 and their reduction products with PM2 DNA

✍ Scribed by Blatter, Erich E.; Vollano, Jean F.; Krishnan, Bala S.; Dabrowiak, James C.

Book ID
121461715
Publisher
American Chemical Society
Year
1984
Tongue
English
Weight
900 KB
Volume
23
Category
Article
ISSN
0006-2960

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DNA-platinum interactions in vitro with
DNA-platinum interactions in vitro with trans- and cis- Pt(NH3)2Cl2
✍ Jean-Pierre Macquet; Theophile Theophanides πŸ“‚ Article πŸ“… 1975 πŸ› Elsevier Science βš– 434 KB

In the present study the nature and the hydrolysis of DNA-I% complexes with the platinum compounds, [Pt(dien)C1]Cl, Imns-and ~rlrPt(NH~),Ci,, using potentiometric chloride determinations, have been investigated. The tmns-Pt(NH,),C1, and the [Pt(dien)Cl] Cl react with the GC planes at the N,(G) sites