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Cis-Pt(NH3)2Cl2 and trans-Pt(NH3)2Cl2 inhibit DNA synthesis in cultured L1210 leukemia cells

✍ Scribed by B. Salles; J.L. Butour; C. Lesca; J.P. Macquet

Book ID
115756972
Publisher
Elsevier Science
Year
1983
Tongue
English
Weight
437 KB
Volume
112
Category
Article
ISSN
0006-291X

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πŸ“œ SIMILAR VOLUMES

DNA-platinum interactions in vitro with
DNA-platinum interactions in vitro with trans- and cis- Pt(NH3)2Cl2
✍ Jean-Pierre Macquet; Theophile Theophanides πŸ“‚ Article πŸ“… 1975 πŸ› Elsevier Science βš– 434 KB

In the present study the nature and the hydrolysis of DNA-I% complexes with the platinum compounds, [Pt(dien)C1]Cl, Imns-and ~rlrPt(NH~),Ci,, using potentiometric chloride determinations, have been investigated. The tmns-Pt(NH,),C1, and the [Pt(dien)Cl] Cl react with the GC planes at the N,(G) sites