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Preferential uptake of Aβ1-42 oligomers over fibrils by primary human astrocytes in vitro

✍ Scribed by Henrietta M. Nielsen; Sandra D. Mulder; Piet Eikelenboom; Robert Veerhuis


Book ID
118464635
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
42 KB
Volume
5
Category
Article
ISSN
1552-5260

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✍ Henrietta M. Nielsen; Robert Veerhuis; Bo Holmqvist; Sabina Janciauskiene 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 532 KB

## Abstract Clearance of the amyloid‐β peptide (Aβ) as a remedy for Alzheimer's disease (AD) is a major target in on‐going clinical trials. __In vitro__ studies confirmed that Aβ is taken up by rodent astrocytes, but knowledge on human astrocyte‐mediated Aβ clearance is sparse. Therefore, by means