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P1-495: Amyloid beta 1-42 binding and uptake by primary human astrocytes in vitro: Effects of alpha1-antichymotrypsin

✍ Scribed by Nielsen, Henrietta M.; Janciauskiene, Sabina; Holmqvist, Bo; Veerhuis, Robert


Book ID
123177570
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
65 KB
Volume
4
Category
Article
ISSN
1552-5260

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Binding and uptake of Aβ1-42 by primary
✍ Henrietta M. Nielsen; Robert Veerhuis; Bo Holmqvist; Sabina Janciauskiene 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 532 KB

## Abstract Clearance of the amyloid‐β peptide (Aβ) as a remedy for Alzheimer's disease (AD) is a major target in on‐going clinical trials. __In vitro__ studies confirmed that Aβ is taken up by rodent astrocytes, but knowledge on human astrocyte‐mediated Aβ clearance is sparse. Therefore, by means