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Amyloid-associated proteins differentially modulate Aβ1-42 uptake in primary human microglia and astrocytes

✍ Scribed by Mulder, Sandra D.; Nielsen, Henrietta M.; Eikelenboom, Piet; Veerhuis, Robert

Book ID
123051728
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
42 KB
Volume
6
Category
Article
ISSN
1552-5260

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✍ Henrietta M. Nielsen; Robert Veerhuis; Bo Holmqvist; Sabina Janciauskiene 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 532 KB

## Abstract Clearance of the amyloid‐β peptide (Aβ) as a remedy for Alzheimer's disease (AD) is a major target in on‐going clinical trials. __In vitro__ studies confirmed that Aβ is taken up by rodent astrocytes, but knowledge on human astrocyte‐mediated Aβ clearance is sparse. Therefore, by means