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Predictors of Sensitivity and Resistance to Epidermal Growth Factor Receptor Inhibitors

โœ Scribed by Sofia Perea; Manuel Hidalgo

Book ID
115076574
Publisher
CIG Media Group, LP.
Year
2004
Tongue
English
Weight
143 KB
Volume
6
Category
Article
ISSN
1525-7304

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The association/dissociation binding kinetics of 1251-labeled mouse epidermal growth factor (EGF) to receptors on human fibroblast cells in monolayer culture have been measured at 4ยฐC as a function of extracellular pH from pH 5-9. At pH 8, steady-state total binding is maximal. As pH is lowered to 6