Predictors of cancer progression in T1a prostate adenocarcinoma

✍ Scribed by Liang Cheng; Erik J. Bergstralh; Beth G. Scherer; Roxann M. Neumann; Michael L. Blute; Horst Zincke; David G. Bostwick

• Publisher: John Wiley and Sons
• Year: 1999
• Tongue: English
• Weight: 82 KB
• Volume: 85
• Category: Article
• ISSN: 0008-543X
• DOI: 10.1002/(sici)1097-0142(19990315)85:6<1300::aid-cncr12>3.0.co;2-#

✦ Synopsis

BACKGROUND.

The biologic behavior of T1a prostate adenocarcinoma is variable. A critical issue in the management of patients with T1a prostate adenocarcinoma is to distinguish those who will develop cancer progression from those who will not.

Predictive factors that identify those at high risk of cancer progression are needed to stratify patients for treatment. In the current study the authors attempted to identify such predictors of cancer progression in a large series of untreated patients with lengthy follow-up.

METHODS.

The authors studied 102 patients who were diagnosed with T1a prostate adenocarcinoma (incidental tumor involving Յ 5% of the resected prostatic tissue) at the time they underwent transurethral resection of the prostate (TURP) at the Mayo Clinic between 1960 -1970. None of these patients were treated. Patient ages ranged from 48 -91 years (mean Ϯ standard deviation, 69 Ϯ 7 years). The average weight of the resected prostate tissue was 24 Ϯ18 g (range, 3-115 g; median, 18 g).

Tumor volume was measured by the grid method. Cox proportional hazards models were used to identify factors associated with cancer progression. Survival curves were estimated using the Kaplan-Meier method.