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Vascular density is a predictor of cancer-specific survival in prostatic carcinoma

✍ Scribed by Franck Lissbrant, Ingela; Stattin, Pär; Damber, Jan-Erik; Bergh, Anders

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
287 KB
Volume
33
Category
Article
ISSN
0270-4137

No coin nor oath required. For personal study only.

✦ Synopsis

Background:

Microvessel density has been shown to give prognostic information in a variety of solid tumors, but its role in prostatic carcinoma needs further elucidation.

Methods:

Intratumoral density of von willebrand factor-positive microvessels was assessed in 98 cases of prostatic carcinoma, diagnosed at transurethral resection of the prostate (turp) between 1975-1983, using two methods: 1) volume density of microvessels and 2) vascular count in the 2-3 most vascularized fields.

Results:

Volume density and vascular counts were highly correlated. in kaplan-meyer analysis, mean cancer-specific survival time for patients with a vascular count < 135 was significantly longer than for patients with a vascular count > 135 (p = 0.0064). the same results applied to patients with who grade ii tumors (p = 0.01). excluding metastasis in a multivariate analysis, both tumor stage and vascular count had an independent predictive value for cancer-specific survival in patients with who grade ii tumors.

Conclusions:

Microvessel density may predict cancer-specific survival in prostatic carcinoma.

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