The greatest dimension of prostate carcinoma is a simple, inexpensive predictor of prostate specific antigen failure in radical prostatectomy specimens

✍ Scribed by Andrew A. Renshaw; Jerome P. Richie; Kevin R. Loughlin; Michael Jiroutek; Arnold Chung; Anthony V. D'Amico

• Publisher: John Wiley and Sons
• Year: 1998
• Tongue: English
• Weight: 68 KB
• Volume: 83
• Category: Article
• ISSN: 0008-543X
• DOI: 10.1002/(sici)1097-0142(19980815)83:4<748::aid-cncr17>3.0.co;2-s

✦ Synopsis

BACKGROUND.

Tumor volume in radical prostatectomies can be determined by several different techniques and appears to predict clinical progression. Greatest tumor dimension and area are easily obtained measures that are both correlated with tumor volume. The authors sought to determine whether greatest tumor dimension and/or area were predictors of prostate specific antigen (PSA) failure in men who underwent radical prostatectomy for adenocarcinoma of the prostate.

METHODS.

Fifty-seven men with prostate carcinoma who underwent surgical resection were followed for a median of 27.2 months (range, 1-112 months); 24 (42%) of these men had PSA failure. Preoperative PSA, Gleason grade, pathologic stage, margin status, and greatest tumor dimension and area were determined, and both univariate and multivariate analyses of the outcomes of PSA failure were performed.