Endothelium-derived factors as paracrine mediators of prostate cancer progression
✍ Scribed by Georgi Pirtskhalaishvili; Joel B. Nelson
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 207 KB
- Volume
- 44
- Category
- Article
- ISSN
- 0270-4137
No coin nor oath required. For personal study only.
✦ Synopsis
BACKGROUND. Vascular endothelium represents a complex network of cells producing a large number of active substrates affecting physiologic, metabolic, and immunologic properties of the whole organism, as well as particular organs or tissues. The potential influence of endothelium-derived paracrine factors on prostate cancer progression has only begun to be examined. METHODS. This review summarizes recent literature on endothelium-derived factors, including vasoactive agents, peptide growth factors, cytokines, and colony-stimulating factors, involved in the development and progression of prostate cancer. RESULTS. Endothelial cells produce an array of active substrates, many of which have been shown to influence prostate cancer growth.