๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Prediction of Human Bioavailability from Human Oral Administration Data and Animal Pharmacokinetic Data Without Data from Intravenous Administration of Drugs in Humans

โœ Scribed by Haruo Imawaka; Kiyomi Ito; Yoshiaki Kitamura; Kiyoshi Sugiyama; Yuichi Sugiyama

Book ID
106493783
Publisher
Springer US
Year
2009
Tongue
English
Weight
208 KB
Volume
26
Category
Article
ISSN
0724-8741

No coin nor oath required. For personal study only.

๐Ÿ“œ SIMILAR VOLUMES

Prediction of human pharmacokinetics fro
Prediction of human pharmacokinetics from animal data and molecular structural parameters using multivariate regression analysis: Oral clearance
โœ Toshihiro Wajima; Kazuya Fukumura; Yoshitaka Yano; Takayoshi Oguma ๐Ÿ“‚ Article ๐Ÿ“… 2003 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 145 KB

The aim of the study reported here was to develop a regression equation for predicting oral clearance of various kinds of drugs in humans using experimental data from rats and dogs and molecular structural parameters. The data concerning the oral clearance of 87 drugs from rats, dogs, and humans wer

Estimation of the extent of oral absorpt
Estimation of the extent of oral absorption in animals from oral and intravenous pharmacokinetic data in drug discovery
โœ Amin A. Nomeir; Richard Morrison; Daniel Prelusky; Walter Korfmacher; Lisa Brosk ๐Ÿ“‚ Article ๐Ÿ“… 2009 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 163 KB

Oral administration is the most desirable route of drug delivery for systemically active drugs. Oral drugs must possess a certain level of oral bioavailability, which is a product of oral absorption and first-pass effect. Low oral bioavailability may be attributed to poor absorption and/or high firs