𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Pharmacokinetic scale-up: Accurate prediction of human pharmacokinetic profiles from animal data

✍ Scribed by Joyce Mordenti

Publisher
John Wiley and Sons
Year
1985
Tongue
English
Weight
318 KB
Volume
74
Category
Article
ISSN
0022-3549

No coin nor oath required. For personal study only.

πŸ“œ SIMILAR VOLUMES

Prediction of human pharmacokinetic prof
Prediction of human pharmacokinetic profile in animal scale up based on normalizing time course profiles
✍ Toshihiro Wajima; Yoshitaka Yano; Kazuya Fukumura; Takayoshi Oguma πŸ“‚ Article πŸ“… 2004 πŸ› John Wiley and Sons 🌐 English βš– 158 KB

The aim of the present study was to develop a method for predicting the concentration-time profile in humans based on pharmacokinetic data for animals. The method is based on the assumptions that concentration-time profiles of a drug are similar among species and "normalized curves" from a variety o

Prediction of human pharmacokinetics fro
Prediction of human pharmacokinetics from animal data and molecular structural parameters using multivariate regression analysis: Oral clearance
✍ Toshihiro Wajima; Kazuya Fukumura; Yoshitaka Yano; Takayoshi Oguma πŸ“‚ Article πŸ“… 2003 πŸ› John Wiley and Sons 🌐 English βš– 145 KB

The aim of the study reported here was to develop a regression equation for predicting oral clearance of various kinds of drugs in humans using experimental data from rats and dogs and molecular structural parameters. The data concerning the oral clearance of 87 drugs from rats, dogs, and humans wer