The aim of the present study was to develop a method for predicting the concentration-time profile in humans based on pharmacokinetic data for animals. The method is based on the assumptions that concentration-time profiles of a drug are similar among species and "normalized curves" from a variety o
✦ LIBER ✦
Prediction of Pharmacokinetic Profile of Valsartan in Humans Based on in vitro Uptake-Transport Data
✍ Scribed by Agnès Poirier; Anne-Christine Cascais; Christoph Funk; Thierry Lavé
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 306 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1612-1872
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The steady-state and terminal volumes of distribution, as well as the mean residence time of drug in the body (V ss , V $ , and MRT) are the common pharmacokinetic parameters calculated using the drug plasma concentration-time profile C p (t) following intravenous (i.v. bolus or constant rate infusi