𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Prediction of Hepatic Clearance in Human FromIn VitroData for Successful Drug Development

✍ Scribed by Masato Chiba; Yasuyuki Ishii; Yuichi Sugiyama

Book ID
111767559
Publisher
American Association of Pharmaceutical Scientists
Year
2009
Tongue
English
Weight
520 KB
Volume
11
Category
Article
ISSN
1550-7416

No coin nor oath required. For personal study only.

πŸ“œ SIMILAR VOLUMES

Prediction of drug bioavailability in hu
Prediction of drug bioavailability in humans using immobilized artificial membrane phosphatidylcholine column chromatography and in vitro hepatic metabolic clearance
✍ Beom Soo Shin; Chi Ho Yoon; Joseph P. Balthasar; Bu Young Choi; Seok Hyun Hong; πŸ“‚ Article πŸ“… 2009 πŸ› John Wiley and Sons 🌐 English βš– 487 KB

## Abstract This study reports a rapid screening method for the prediction of oral drug bioavailability in humans based on combined immobilized artificial membrane (IAM) chromatographic capacity factor (__k__~IAM~) and __in vitro__ stability in hepatic microsomes. The fraction of drug absorbed (__F