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Comparative assessment of In Vitro–In Vivo extrapolation methods used for predicting hepatic metabolic clearance of drugs

✍ Scribed by Patrick Poulin; Cornelis E. C. A. Hop; Quynh Ho; Jason S. Halladay; Sami Haddad; Jane R. Kenny


Book ID
115559198
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
441 KB
Volume
101
Category
Article
ISSN
0022-3549

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## Abstract This study reports a rapid screening method for the prediction of oral drug bioavailability in humans based on combined immobilized artificial membrane (IAM) chromatographic capacity factor (__k__~IAM~) and __in vitro__ stability in hepatic microsomes. The fraction of drug absorbed (__F