𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Prediction of In Vivo Hepatic Clearance and Half-Life of Drug Candidates in Human Using Chimeric Mice with Humanized Liver

✍ Scribed by Sanoh, S.; Horiguchi, A.; Sugihara, K.; Kotake, Y.; Tayama, Y.; Ohshita, H.; Tateno, C.; Horie, T.; Kitamura, S.; Ohta, S.


Book ID
118010480
Publisher
American Society for Pharmacology and Experimental Therapeutics
Year
2011
Tongue
English
Weight
951 KB
Volume
40
Category
Article
ISSN
0090-9556

No coin nor oath required. For personal study only.


πŸ“œ SIMILAR VOLUMES


In vivo drug metabolism model for human
✍ Miki Katoh; Toshiro Sawada; Yoshinori Soeno; Miki Nakajima; Chise Tateno; Katsut πŸ“‚ Article πŸ“… 2007 πŸ› John Wiley and Sons 🌐 English βš– 150 KB

We previously clarified that major human drug metabolizing enzymes were expressed in a chimeric urokinase-type plasminogen activator (uPA)+/+/severe combined immunodeficient (SCID) mouse line established recently, in which the liver could be replaced by more than 80% with human hepatocytes. In the p

Prediction of drug bioavailability in hu
✍ Beom Soo Shin; Chi Ho Yoon; Joseph P. Balthasar; Bu Young Choi; Seok Hyun Hong; πŸ“‚ Article πŸ“… 2009 πŸ› John Wiley and Sons 🌐 English βš– 487 KB

## Abstract This study reports a rapid screening method for the prediction of oral drug bioavailability in humans based on combined immobilized artificial membrane (IAM) chromatographic capacity factor (__k__~IAM~) and __in vitro__ stability in hepatic microsomes. The fraction of drug absorbed (__F