We previously clarified that major human drug metabolizing enzymes were expressed in a chimeric urokinase-type plasminogen activator (uPA)+/+/severe combined immunodeficient (SCID) mouse line established recently, in which the liver could be replaced by more than 80% with human hepatocytes. In the p
β¦ LIBER β¦
Prediction of In Vivo Hepatic Clearance and Half-Life of Drug Candidates in Human Using Chimeric Mice with Humanized Liver
β Scribed by Sanoh, S.; Horiguchi, A.; Sugihara, K.; Kotake, Y.; Tayama, Y.; Ohshita, H.; Tateno, C.; Horie, T.; Kitamura, S.; Ohta, S.
- Book ID
- 118010480
- Publisher
- American Society for Pharmacology and Experimental Therapeutics
- Year
- 2011
- Tongue
- English
- Weight
- 951 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0090-9556
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
In vivo drug metabolism model for human
β
Miki Katoh; Toshiro Sawada; Yoshinori Soeno; Miki Nakajima; Chise Tateno; Katsut
π
Article
π
2007
π
John Wiley and Sons
π
English
β 150 KB
Utility of Hepatocytes in Predicting Dru
β
Naritomi, Y.
π
Article
π
2003
π
American Society for Pharmacology and Experimental
π
English
β 293 KB
Identification of human cytochrome P450s
β
Xue-Qing Li; Anders BjΓΆrkman; TommyB. Andersson; LarsL. Gustafsson; CollenM. Mas
π
Article
π
2003
π
Springer
π
English
β 363 KB
Prediction of drug bioavailability in hu
β
Beom Soo Shin; Chi Ho Yoon; Joseph P. Balthasar; Bu Young Choi; Seok Hyun Hong;
π
Article
π
2009
π
John Wiley and Sons
π
English
β 487 KB
## Abstract This study reports a rapid screening method for the prediction of oral drug bioavailability in humans based on combined immobilized artificial membrane (IAM) chromatographic capacity factor (__k__~IAM~) and __in vitro__ stability in hepatic microsomes. The fraction of drug absorbed (__F
Combining in Vitro and in Vivo Pharmacok
β
Schneider, Gisbert; Coassolo, Philippe; LavΓ©, Thierry
π
Article
π
1999
π
American Chemical Society
π
English
β 60 KB
[Methods in Molecular Biology] Hepatocyt
β
Maurel, Patrick
π
Article
π
2010
π
Humana Press
β 927 KB