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Prediction of drug binding to melanin using a melanin-based high-performance liquid chromatographic stationary phase and chemometric analysis of the chromatographic data

✍ Scribed by Roman Kaliszan; Anna Kaliszan; Irving W. Wainer

Publisher
Elsevier Science
Year
1993
Weight
691 KB
Volume
615
Category
Article
ISSN
0378-4347

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✍ H. Ibrahim; A.F. Aubry πŸ“‚ Article πŸ“… 1995 πŸ› Elsevier Science 🌐 English βš– 476 KB

Drug-melanin interactions were studied using a melanin-based HPLC column. Two approaches were chosen for the preparation of the stationary phases: covalent coupling of synthetic L-dopa melanin and in situ polymerization of L-dopa. Retention of a series of phenothiazines on melanin-based stationary p