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Predicting protein structure using only sequence information

✍ Scribed by Kevin Karplus; Christian Barrett; Melissa Cline; Mark Diekhans; Leslie Grate; Richard Hughey

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
111 KB
Volume
37
Category
Article
ISSN
0887-3585

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✦ Synopsis

This paper presents results of blind predictions submitted to the CASP3 protein structure prediction experiment. We made predictions using the SAM-T98 method, an iterative hidden Markov model-based method for constructing protein family profiles. The method is purely sequencebased, using no structural information, and yet was able to predict structures as well as all but five of the structure-based methods in CASP3. Proteins

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