Application of multiple sequence alignment profiles to improve protein secondary structure prediction

Evaluation and improvement of multiple s

Evaluation and improvement of multiple sequence methods for protein secondary structure prediction

✍ James A. Cuff; Geoffrey J. Barton 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 166 KB 👁 1 views

A new dataset of 396 protein domains is developed and used to evaluate the performance of the protein secondary structure prediction algorithms DSC, PHD, NNSSP, and PREDATOR. The maximum theoretical Q 3 accuracy for combination of these methods is shown to be 78%. A simple consensus prediction on th