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Successful recognition of protein folds using threading methods biased by sequence similarity and predicted secondary structure

✍ Scribed by David T. Jones; Michael Tress; Kevin Bryson; Caroline Hadley

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 252 KB
Volume: 37
Category: Article
ISSN: 0887-3585
DOI: 10.1002/(sici)1097-0134(1999)37:3+<104::aid-prot14>3.0.co;2-p

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✦ Synopsis

Analysis of our fold recognition results in the 3rd Critical Assessment in Structure Prediction (CASP3) experiment, using the programs THREADER 2 and GenTHREADER, shows an encouraging level of overall success. Of the 23 submitted predictions, 20 targets showed no clear sequence similarity to proteins of known 3D structure. These 20 targets can be divided into 22 domains, of which, 20 domains either entirely match a previously known fold, or partially match a substantial region of a known fold. Of these 20 domains, we correctly assigned the folds in 10 cases. Proteins

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