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Predicting Oral Clearance in Humans

✍ Scribed by Vikash K. Sinha, Stefan S. De Buck, Luca A. Fenu, Johan W. Smit, Marjoleen Nijsen, Ron A. H. J. Gilissen, Achiel Van Peer, Karel Lavrijsen, Claire E. Mackie

Book ID
119926842
Publisher
Springer International Publishing AG
Year
2008
Tongue
English
Weight
158 KB
Volume
47
Category
Article
ISSN
0312-5963

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Values for V,, and K, determined during the in vitro metabolism of a xenobiotic to a known metabolite by a specific human isozyme of cytochrome P450 (P450) were used to predict the hepatic clearance (CLH) of the xenobiotic to that metabolite. The calculated CLH values were then compared to literatur