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Predicting oral drug absorption and hepatobiliary clearance: Human intestinal and hepatic in vitro cell models

✍ Scribed by Richard A. Fearn; Barry H. Hirst


Book ID
116454470
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
270 KB
Volume
21
Category
Article
ISSN
1382-6689

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## Abstract This study reports a rapid screening method for the prediction of oral drug bioavailability in humans based on combined immobilized artificial membrane (IAM) chromatographic capacity factor (__k__~IAM~) and __in vitro__ stability in hepatic microsomes. The fraction of drug absorbed (__F