Predictability of verapamil steady-state plasma levels from single-dose data explained
β Scribed by Wagner, John G
- Book ID
- 109843374
- Publisher
- Nature Publishing Group
- Year
- 1984
- Tongue
- English
- Weight
- 206 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0009-9236
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π SIMILAR VOLUMES
Simulated data using a linear one-and two-compartment body model with different absorption characteristics were used to evaluate the ability of single dose bioavailability data to predict the relationships that exist at steady state. This was done by comparing the confidence intervals obtained from
Two nonlinear pharmacokinetic models were simulated to investigate the relationship between single and multiple dose bioequivalency parameters for drugs such as phenytoin and propranolol which exhibit either saturable elimination kinetics or a capacity limited first pass effect. Mean T,,,, C, , , an