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Preclinical Studies on Aryl Phosphate Derivatives of Bromo-Methoxy Zidovudine (Compounds WHI-05 and WHI-07): Novel Contraceptives with Anti-HIV Activity

✍ Scribed by O.J D’Cruz; F.M Uckun

Book ID: 119416141
Publisher: Elsevier Science
Year: 2000
Tongue: English
Weight: 23 KB
Volume: 74
Category: Article
ISSN: 1556-5653
DOI: 10.1016/s0015-0282(00)00915-8

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## Abstract __5‐bromo‐6‐methoxy‐5,6‐dihydro‐3^′^‐azidothymidine‐5^′^‐(p‐bromophenyl) methoxyalaninyl phosphate__ (WHI‐07), a novel bromo‐methoxy‐substituted aryl phosphate derivative of zidovudine (ZDV), is a potent dual‐function contraceptive agent with anti‐HIV activity. Its potential for reprodu