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In vivo contraceptive activity of novel dual-function microbicides: aryl phosphate derivatives of bromo-methoxy zidovudine (compounds WHI-05 and WHI-07)

✍ Scribed by Osmond J D’Cruz; Fatih M Uckun

Book ID: 119419054
Publisher: Elsevier Science
Year: 2002
Tongue: English
Weight: 18 KB
Volume: 78
Category: Article
ISSN: 1556-5653
DOI: 10.1016/s0015-0282(02)03441-6

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## Abstract __5‐bromo‐6‐methoxy‐5,6‐dihydro‐3^′^‐azidothymidine‐5^′^‐(p‐bromophenyl) methoxyalaninyl phosphate__ (WHI‐07), a novel bromo‐methoxy‐substituted aryl phosphate derivative of zidovudine (ZDV), is a potent dual‐function contraceptive agent with anti‐HIV activity. Its potential for reprodu