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Pre-column derivatization of aminoglycosides with 1-fluoro-2,4-dinitrobenzene

✍ Scribed by D.M. Barends; J.S. Blauw; C.W. Mijnsbergen; C.J.L.R. Govers; A. Hulshoff

Book ID
104146629
Publisher
Elsevier Science
Year
1985
Tongue
English
Weight
653 KB
Volume
322
Category
Article
ISSN
1873-3778

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✦ Synopsis

The reaction between tobramycin and I-fluoro-2,4dinitrobenzene was studied. This reaction shows a sharp pH optimum because, even under moderate alkaline conditions, derivatization of the aliphatic hydroxyl groups of tobramycin becomes an important side reaction. Phosphate and phthalate buffers also react with the derivatization reagent. Buffers comprising tertiary amines and hydrochloric acid are preferred.

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