The reaction between tobramycin and I-fluoro-2,4dinitrobenzene was studied. This reaction shows a sharp pH optimum because, even under moderate alkaline conditions, derivatization of the aliphatic hydroxyl groups of tobramycin becomes an important side reaction. Phosphate and phthalate buffers also
Fast pre-column derivatization of aminoglycosides with 1-fluoro-2,4-dinitrobenzene and its application to pharmaceutical analysis
โ Scribed by D.M. Barends; J.C.A.M. Brouwers; A. Hulshoff
- Book ID
- 103910901
- Publisher
- Elsevier Science
- Year
- 1987
- Tongue
- English
- Weight
- 319 KB
- Volume
- 5
- Category
- Article
- ISSN
- 0731-7085
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Cationic micelles have been used for the derivatization of the anti-Parkinson drug amantadine with the chromophore 1-fluoro-2,4-dinitrobenzene in urine. In the presence of 90 mM cetyltrimethylammonium bromide (CTAB), the conversion of amantadine into its derivative is complete within 4 min at 60 deg
Ion-exchanger phase absorptlometry was applied to flow analysis for trace amounts of copper in water The increase m the absorbance of the coloured complex wth 4,7-d~phenyl-2,9-d~methyl-1,l0-phenanthrolme dlsulphonate, which was concentrated on-line on to an ion exchanger packed m a flow-through cell