Pre-clinical evaluation of cyclin-dependent kinase 2 and 1 inhibition in anti-estrogen-sensitive and resistant breast cancer cells
โ Scribed by Johnson, N; Bentley, J; Wang, L-Z; Newell, D R; Robson, C N; Shapiro, G I; Curtin, N J
- Book ID
- 110000286
- Publisher
- Nature Publishing Group
- Year
- 2009
- Tongue
- English
- Weight
- 735 KB
- Volume
- 102
- Category
- Article
- ISSN
- 0007-0920
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3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase catalyzes the formation of mevalonate, a precursor of cholesterol that is also required for cell proliferation. Mevalonate depletion results in a G1 phase cell cycle arrest that is mediated in part by impaired activity of cyclin-dependent kin