pRb suppresses camptothecin-induced apoptosis in human osteosarcoma Saos-2 cells by inhibiting c-Jun N-terminal kinase
✍ Scribed by Marianna Lauricella; Giuseppe Calvaruso; Maria Carabillò; Antonella D’Anneo; Michela Giuliano; Sonia Emanuele; Renza Vento; Giovanni Tesoriere
- Book ID
- 117103102
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 296 KB
- Volume
- 499
- Category
- Article
- ISSN
- 0014-5793
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract To elucidate the possible effect of NFκB on radioresistance, we used the osteosarcoma cell line Saos2, stably expressing the NFκB constitutive inhibitor, mIκB (Saos2‐mIκB) or stably transfected with the empty vector (Saos2‐EV). Ionizing radiation induced “intrinsic” apoptosis in Saos2‐m
Methylglyoxal (MG) is a physiological metabolite, but it is known to be toxic, inducing stress in cells and causing apoptosis. This study examines molecular mechanisms in the MG-induced signal transduction leading to apoptosis, focusing particularly on the role of JNK activation. We first confirmed